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June 23, 2023 at 1:17:50 AM

Male Pattern Baldness & Female Pattern Hair Loss

Pioneering Hair Regrowth Solutions with Stem Cell Culture Supernatant

Male Pattern Baldness & Female Pattern Hair Loss

At Acalah, we understand the emotional toll that hair loss can have on both men and women. We believe that everyone deserves to feel confident and proud of their appearance, without the burden of hair loss weighing them down. That's why we are passionate about harnessing the power of stem cell culture supernatant to revolutionize the field of hair regrowth.

Traditionally, hair loss has been attributed primarily to genetic factors, leading many to believe that it is an inevitable and irreversible condition. This perception has left individuals feeling helpless and resigned to their fate. While genetic factors do play a significant role, we must not overlook the fact that our scalps were once teeming with healthy hair during our youth. This realization fuels our vision to reverse time and restore the scalp's cellular state to its former glory, naturally stimulating the regrowth of hair without invasive surgeries or biologically taxing interventions.

Acalah's groundbreaking approach lies in our stem cell culture supernatant, which is derived from meticulously cultured stem cells. Stem cell culture supernatant is a liquid rich in growth factors, cytokines, and paracrine signaling molecules that can rejuvenate and activate the dormant potential of hair follicles. By providing a nourishing environment and stimulating the proliferation of cells within the hair follicles, our innovative solution helps to reverse the effects of hair loss at a cellular level.

We are committed to conducting rigorous research and adhering to the highest standards to ensure the safety and efficacy of our products. Our dedicated team of scientists, researchers, and dermatologists work tirelessly to unlock the full potential of stem cell culture supernatant for hair regrowth. We aim to provide individuals with a natural and non-invasive solution that can restore their confidence and help them regain a vibrant and healthy head of hair.

At Acalah, our vision is to transform the landscape of hair loss treatment, offering a ray of hope to those struggling with hair loss. We believe that by harnessing the power of science and nature, we can empower individuals to regain control over their appearance and embrace their true selves with newfound confidence. Join us on this journey as we redefine what is possible in the realm of hair regrowth and help individuals rediscover their beauty from within.

What are Male Pattern Baldness & Female Pattern Hair Loss?

Male Pattern Baldness (Androgenetic Alopecia): 

Male pattern baldness, or androgenetic alopecia, is a common hair loss condition that affects men. It is characterized by a progressive and predictable pattern of hair thinning and loss, primarily at the front and top of the scalp. This pattern is often referred to as the "Norwood-Hamilton scale."

The underlying cause of male pattern baldness involves a combination of genetic predisposition and hormonal factors. Genetic factors play a significant role, as the condition tends to run in families. Variations in several genes have been implicated in the development of male pattern baldness. One of these genes is the androgen receptor gene, located on the X chromosome, which influences the body's response to androgen hormones.


The primary hormonal influence in male pattern baldness is dihydrotestosterone (DHT), a derivative of testosterone. DHT binds to androgen receptors on hair follicles, particularly those on the top and front of the scalp, causing them to shrink and produce thinner, shorter hairs. Over time, the affected hair follicles may become unable to produce new hairs, leading to the appearance of baldness.

Male pattern baldness typically begins with a receding hairline, often forming an "M" shape. Hair thinning may also occur at the crown (vertex) of the head. As the condition progresses, these areas of hair loss can merge, leaving a horseshoe-shaped ring of hair around the sides and back of the head.

The age at which male pattern baldness starts can vary. It commonly begins in adulthood, with the first signs appearing in the late teens or early twenties. However, some men may experience hair loss as early as their teenage years, while others may not notice significant thinning until later in life.


Female Pattern Hair Loss (Androgenetic Alopecia):

Female pattern hair loss, or androgenetic alopecia, is the most common form of hair loss in women. It is characterized by a diffuse thinning of the hair across the scalp, often with preservation of the frontal hairline. Unlike male pattern baldness, female pattern hair loss rarely leads to complete baldness.

The causes of female pattern hair loss are similar to those of male pattern baldness. Genetic factors play a role, and certain genes involved in androgen metabolism and the androgen receptor gene have been associated with this condition. However, the inheritance pattern in women appears to be more complex and less well understood than in men.


Androgens, including testosterone and DHT, also contribute to female pattern hair loss, although to a lesser extent compared to men. It is believed that the sensitivity of hair follicles to androgens, rather than the absolute levels of these hormones, is more relevant in female pattern hair loss.

Female pattern hair loss can occur at any age, but it is most commonly observed after menopause. Hormonal changes during menopause can affect the hair growth cycle and lead to increased hair shedding and thinning. Other hormonal changes, such as those occurring during pregnancy or after discontinuing birth control pills, can also trigger or worsen female pattern hair loss.


While male pattern baldness (androgenetic alopecia) and female pattern hair loss (androgenetic alopecia) share similarities, there are several key differences between the two conditions:


1. Pattern of Hair Loss: 

  • Male Pattern Baldness: In men, the hair loss pattern typically starts with a receding hairline, forming an "M" shape, and progresses to thinning at the crown (vertex) of the head. Over time, these areas of hair loss may merge, resulting in partial or complete baldness on the top of the scalp, leaving a horseshoe-shaped ring of hair around the sides and back of the head.


  • Female Pattern Hair Loss: In women, hair loss is characterized by a diffuse thinning of hair across the scalp, with preservation of the frontal hairline. Hair thinning is often more evenly distributed, and complete baldness is rare. Women may notice a widening part line or overall reduction in hair density.


2. Hormonal Factors: 

  • Male Pattern Baldness: Androgens, particularly dihydrotestosterone (DHT), play a prominent role in male pattern baldness. DHT binds to androgen receptors on hair follicles, causing them to shrink and produce thinner, shorter hairs. Genetic factors and the sensitivity of hair follicles to DHT contribute to the condition.


  • Female Pattern Hair Loss: Androgens, including testosterone and DHT, also play a role in female pattern hair loss. However, the influence of androgens in women is typically less pronounced compared to men. Factors such as the sensitivity of hair follicles to androgens, hormonal changes during menopause, and genetic factors contribute to the development of female pattern hair loss.


3. Presentation and Severity: 

  • Male Pattern Baldness: Men with androgenetic alopecia commonly experience more pronounced hair loss, and the progression can be more rapid compared to women. Complete baldness is possible in male pattern baldness, especially on the top of the scalp.


  • Female Pattern Hair Loss: Women generally experience a more gradual thinning of hair without significant bald patches. The hair loss is typically diffuse and may be more challenging to notice in the early stages. Female pattern hair loss rarely leads to complete baldness.


Age of Onset:

  • Male Pattern Baldness: Male pattern baldness can start as early as the late teens or early twenties. However, the age of onset can vary, and some men may not notice significant hair loss until later in life.


  • Female Pattern Hair Loss: Female pattern hair loss can occur at any age, but it is most commonly observed after menopause. Hormonal changes during menopause can affect the hair growth cycle and contribute to hair thinning in women.


It's important to note that these are general trends, and individual experiences of hair loss can vary. It's recommended to consult with a healthcare professional or a dermatologist for an accurate diagnosis and personalized treatment options.

How can Stem Cell Culture Supernatant Help Hair Loss?

Stem cell culture supernatant promotes hair regrowth in a very versatile way, and many preclinical studies and initial clinical observations have shown positive results.


Stem cell culture supernatant contains various factors, including growth factors, cytokines, and paracrine signaling molecules, which support hair regrowth. These factors can stimulate the proliferation of cells in the hair follicles, promote the transition of resting follicles to active growth phases, and activate dormant follicles. Additionally, stem cell culture supernatant may have anti-inflammatory effects, help maintain a healthy extracellular matrix in the skin, and enhance blood circulation to the scalp, which provides a conducive environment for hair regrowth.


Growth Factors and Cytokines: 

Stem cell culture supernatant contains various growth factors and cytokines that can benefit hair growth. These include vascular endothelial growth factor (VEGF), insulin-like growth factor (IGF), transforming growth factor-beta (TGF-beta), and platelet-derived growth factor (PDGF), among others. These growth factors play essential roles in regulating cell growth, survival, and tissue repair. In the context of hair loss, they can stimulate the proliferation of cells in the hair follicles, promote the elongation of hair shafts, and enhance blood circulation to the scalp. Improved blood flow can provide necessary nutrients and oxygen to hair follicles, supporting their overall health and function.


Anti-inflammatory Effects:

Chronic inflammation can contribute to hair loss conditions such as androgenetic alopecia. Stem cell culture supernatant may possess anti-inflammatory properties, helping to reduce inflammation in the scalp and hair follicles. By suppressing inflammatory responses, it can create a more favorable environment for hair growth and prevent further hair loss. This anti-inflammatory effect can help counteract the damaging effects of inflammation on hair follicles and promote their regeneration.


Paracrine Signaling:

Stem cells have the ability to secrete various signaling molecules and microvesicles, such as exosomes. These secreted factors can act as paracrine signals, influencing nearby cells and tissues. Stem cell culture supernatant contains these paracrine signaling molecules that can positively impact hair follicle function. They can stimulate the proliferation and differentiation of cells in the hair follicles, promote the transition of resting hair follicles to active growth phases, and potentially activate dormant hair follicles. These signaling molecules may also help regulate the hair growth cycle and maintain a balance between hair growth and shedding.


Extracellular Matrix Remodeling:

Stem cell culture supernatant may promote extracellular matrix remodeling in the scalp. The extracellular matrix provides structural support to the hair follicles and plays a crucial role in hair growth. Stem cell-derived factors present in the culture supernatant can enhance the production of collagen, elastin, and other extracellular matrix components. This remodeling can help create a healthy environment for hair follicles to grow and thrive. Improved extracellular matrix quality and composition can support the anchoring of hair follicles and facilitate the growth of healthy, strong hair strands.

Male Pattern Baldness & Female Pattern Hair Loss

​根拠及び研究論文

Fukuoka H, Suga H. Hair Regeneration Treatment Using Adipose-Derived Stem Cell Conditioned Medium: Follow-up With Trichograms. Eplasty. 2015;15:e10. PMID: 25694894.

Oh JY, Kim MK, Shin MS, et al. The anti-inflammatory and anti-oxidant effects of the adipose-derived stem cell condition medium in an osteoarthritic rat model. J Orthop Res. 2014;32(5):551-556. doi:10.1002/jor.22554.

Choi N, Son D, Choi J, et al. Effect of adipose-derived stem cell-conditioned medium on the proliferation and migration of human dermal fibroblasts. J Dermatol Sci. 2018;92(3):282-285. doi:10.1016/j.jdermsci.2018.10.002.

Paik JY, Nguyen NH, Lee Y, et al. Conditioned medium from human bone marrow-derived mesenchymal stem cells promotes hair growth in mice. Biomolecules. 2019;9(11):736. doi:10.3390/biom9110736.

Hirotaro Fukuoka; Hair Regeneration Therapy: Application of Adipose-Derived Stem Cells; Curr Stem Cell Res Ther. 2017 Oct; 12(7): 531–534.

Hirotaro Fukuoka; Hair Regeneration Treatment Using Adipose-Derived Stem Cell Conditioned Medium: Follow-up With Trichograms; Eplasty. 2015; 15: e10.

Hyoseung Shin; Up-to-date Clinical Trials of Hair Regeneration Using Conditioned Media of Adipose-Derived Stem Cells in Male and Female Pattern Hair Loss; Curr Stem Cell Res Ther. 2017;12(7):524-530.

Hyoseung Shin; Clinical use of conditioned media of adipose tissue-derived stem cells in female pattern hair loss: a retrospective case series study; Int J Dermatol. 2015 Jun;54(6):730-5.

Hamilton JB. Male hormone stimulation is a prerequisite and an incitant in common baldness. Am J Anat. 1942;71(3):451-480. doi:10.1002/aja.1000710306

Hillmer AM, Flaquer A, Hanneken S, et al. Genome-wide scan and fine-mapping linkage study of androgenetic alopecia reveals a locus on chromosome 3q26. Am J Hum Genet. 2008;82(3):737-743. doi:10.1016/j.ajhg.2007.12.009

Trueb RM. Molecular mechanisms of androgenetic alopecia. Exp Gerontol. 2002;37(8-9):981-990. doi:10.1016/s0531-5565(02)00099-4

Gan DC, Sinclair RD. Prevalence of male and female pattern hair loss in Maryborough. J Investig Dermatol Symp Proc. 2005;10(3):184-189. doi:10.1111/j.1087-0024.2005.10104.x

Hillmer AM, Hanneken S, Ritzmann S, et al. Genetic variation in the human androgen receptor gene is the major determinant of common early-onset androgenetic alopecia. Am J Hum Genet. 2005;77(1):140-148. doi:10.1086/431425

Blume-Peytavi U, Hillmann K. Hair loss. In: Goldsmith LA, Katz SI, Gilchrest BA, Paller AS, Leffell DJ, Wolff K, eds. Fitzpatrick's Dermatology in General Medicine. 9th ed. McGraw-Hill; 2019.

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